The 75 acre blaze broke out around 2:30 p.m. and was burning near the 134 Freeway at Harvey Drive, the Los Angeles Fire Department said.
The 2 Freeway between the 134 Freeway and the 210 Freeway was closed for several hours.
Residents in Chevy Chase Canyon and Glenoaks Canyon were told to evacuate the area.
An evacuation center was set up at the Glendale Adult Recreation Center on 201 East Colorado St.
The Pasadena Humane Society was offering evacuees boarding for pets at no cost.
They are located at 361 S. Raymond Ave.
Night classes at Glendale City College were canceled.
Four helicopters and dozens of firefighters were battling the blaze, according to officials.
Burbank, Pasadena, L.A. City and L.A.County fire departments were also assisting in the fight.
There were no immediate reports of damage or injuries.
Authorities lifted the evacuation order around 9 p.m.