A fatal collision on the southbound I-405 and a separate crash in the northbound lanes Tuesday night forced an hourslong closure of the entire freeway in the Sepulveda Pass near Skirball Center Drive.
A 45-year-old man was pronounced dead at the scene and two other people were in fair condition after a collision involving a motorcyclist in the southbound lanes, according to a tweet from the Los Angeles Police Department.
Three cars were involved in a crash on southbound side that occurred within minutes of the first collision, aerial video showed.
A SigAlert was issued at 9:10 p.m. The freeway was expected to remain closed for at least two hours, according to the California Highway Patrol.
Aerial video showed traffic on both sides of the freeway was backed up for miles during the closure.
The Highway Patrol was urging motorists to take alternate routes.
Officers reopened three lanes on the northbound 405 just after 10:30 p.m. to escort motorists off the freeway at Mulholland Drive.
Drivers on the southbound side of the freeway were being diverted onto Valley Vista Boulevard.
The freeway was reopened around 1:53 a.m., CHP Officer Villalobos said.