A man and woman suffered major injuries in a hit-and-run crash late Sunday night on the 101 Freeway in Sherman Oaks, authorities said.
The collision occurred about 11:53 p.m. on the westbound side of the freeway, just east of the 405 Freeway (map), Officer Tony Polizzi of the California Highway Patrol said.
The two victims were traveling in a white 2006 Honda CR-V that collided with a black 2003 BMW, then rotated and overturned before it came to a stop, blocking multiple lanes.
The BMW also struck a guardrail, causing extensive damage to its front end.
The Honda's occupants were transported to Northridge Hospital Medical Center, according to a CHP press release. The extent of their injuries and their conditions were not immediately known.
The victims were identified only as a 41-year-old male driver from Woodland Hills and a 32-year-old female passenger from Santa Clarita. Both were wearing seatbelts at the time of the incident, according to authorities.
The driver of the BMW fled the crash scene on foot, running from the freeway to surface streets below, the release said.
Air support and K-9 units from the Los Angeles Police Department assisted in a subsequent search, which was suspended about 3:30 a.m. The man remained at large Monday morning.
The cause of the collision was under investigation.
Anyone with information is asked to call the CHP's West Valley office at 818-888-0980.