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12 Dead After ‘Worst NYC Fire’ in 25 Years Rips Through Bronx Apartment Building, Mayor Says

At least 12 people, including a child, were killed in a fire Thursday night at a five-story apartment building in the Bronx, one of New York City's boroughs, officials said. The cause of the blaze is under investigation.

Mayor Bill de Blasio called it the "worst fire tragedy in this city in at least a quarter century."

Four people were critically injured and others were hurt, the mayor said. He added that it's possible that "we may lose others as well."

"This will rank as one of the worst losses of life to a fire in many, many years," de Blasio said in a Thursday press conference.

The fire started on the first floor and spread quickly, said the city's Fire Commissioner Daniel Nigro. The victims, ranging in age from 1 to 50, died on various floors of the apartment building.

The first call about the fire came at 6:51 p.m. ET and the fire department responded within three minutes, Nigro said.

"This tragedy is, without question, historic in its magnitude," he said. "Our hearts go out to every family who lost a loved one here and everyone fighting for their lives."

Shocked residents and family members stood outside the building in frigid temperatures, waiting for news.

A woman, who declined to share her full name with CNN affiliate WPIX, stood anxiously on the street as firefighters wheeled victims out. She said the last text she had gotten from her mother, who lives in the building, was that she was trapped in her third floor apartment.

At least 12 people were rescued and are expected to survive, the mayor said. By the time the officials spoke around 10 p.m. ET, the fire had been put out and the building was being searched.