Flames engulfed a 99 Cents Only Stores location in Culver City early Monday morning.
The fire was reported about 1:45 a.m. at the store in the 12000 block of Washington Boulevard, a fire official at the scene told KTLA.
Video showed the fire was still burning as of 5 a.m. while firefighters continued to spray water into the building.
The structure's roof had already collapsed and some of the walls were beginning to crumble.
The flames were finally doused hours later.
Officials have not yet determined the cause of the fire.
Some nearby residents said they believe the flames started at the back of the store. The store was closed when the fire began.
No injuries were reported and no other businesses were in danger, a spokesperson for the Culver City Police Department said.