Officials reopened the southbound 5 Freeway in the Santa Clarita area, just south of State Route 126, hours after a jackknifed big rig triggered a partial closure early Tuesday.
The crash happened around 5 a.m. and involved a FedEx truck with two trailers and a sedan that caught fire, according to the California Highway Patrol's incident log.
All those involved managed to exit the vehicles, CHP said.
The incident triggered the closure of the Nos. 1, 2 and 3 lanes, Caltrans said. They reopened around 9:40 a.m., according to the agency.
Motorists faced a 35-minute delay with a 4 1/2 mile traffic backup on the freeway, Caltrans tweeted just before 9 a.m.