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A coronavirus variant from Brazil has been detected in a sample from the Bay Area, underscoring the urgency of ramping up inoculation efforts as researchers try to learn whether it, as well as others circulating in California, could undermine the effectiveness of COVID-19 vaccines.

Researchers at Stanford’s Clinical Virology Laboratory screened nearly 1,000 specimens during the last two weeks and found one case of the Brazilian variant, P.2, said Dr. Benjamin Pinsky, the laboratory’s medical director. They reported the finding to public health authorities on Jan. 25.

The researchers also identified four cases of a variant from the U.K., B.1.1.7, that appears to spread more easily, may be more virulent and is already known to be circulating in California, Pinsky said. And they found that about 29% of the specimens had the L452R mutation, a feature of a homegrown variant that has been increasingly detected across the state and may have helped drive the most recent case surge.

“It’s definitely possible that they already contributed to the humongous surge we’ve seen over the last six weeks or so,” said Dr. Edward Jones-Lopez, an infectious diseases expert at USC. “And it could get even worse if these strains are indeed fitter than previous strains and people lower their guard and we are not very logistically efficient in delivering vaccines.

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