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A stretch of the southbound 405 Freeway was closed for several hours in Westchester after a car crash left one man dead and three others injured early Saturday morning, authorities said.

The fatal crash occurred around 2:10 a.m. on the southbound 405 near Howard Hughes Parkway, according to the California Highway Patrol’s incident log. The location is not far from The Promenade at Howard Hughes Center.

One victim, described as a man in his 20s, was pronounced dead at the scene, the Los Angeles Fire Department stated. Three other patients — a 26-year-old woman, a 25-year-old woman and a 25-year-old man — were all transported to a local hospital in fair condition.

Their identities have not been released.

Initial reports indicated that a silver Lexus was “heavily swerving” before it went down an embankment and overturned, according to CHP’s incident log.

CHP Officer Patrick Stafford later said the Lexus clipped a white Mazda before it began to roll over, ejecting one person in the vehicle who was believed to have been driving.

It appeared that the man was not wearing a seat belt at the time, but that remained under investigation, according to Stafford.

“Most of the time when people are ejected, it’s because they didn’t have their seat belt on,” he said.

The Mazda sustained minor damages in the collision, but no one inside the vehicle was injured, according to the CHP officer.

Authorities were still investigating to determine whether speed or drugs and alcohol played a role in the crash, he added.

The southbound lanes were shut down for more than four hours while the investigation was underway, according to CHP.