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Which vitamin B6 supplements are best?

Vitamin B6 is one of the vitamins that your body cannot store, so it is important to get enough from your diet. Furthermore, if you have a liver, kidney, digestive or autoimmune disease, you may be at risk of a deficiency of this vitamin.

Apart from diet, taking a supplement can also help avoid or correct a deficiency. To choose the right vitamin B6 supplement, go for a product that is made to meet the highest quality standards, like Solgar Vitamin B6 25 mg, 100 Tablets.

What to know before you buy a vitamin B6 supplement


If you have kidney disease or a condition that impairs the absorption of nutrients from your small intestine, you may likely be vitamin B6-deficient. Certain medications, like antituberculosis drugs and some epilepsy drugs, can also deplete your vitamin B6 stores. In pregnancy, vitamin B6 plays a crucial role in the development of your baby’s brain and nervous system. However, you shouldn’t exceed the amount you need during this period, because excess vitamin B6 can cause numbness and nerve damage. 

Recommended daily intake

If you are 50 years and younger, it is recommended that you take 1.3 milligrams of vitamin B6 daily. After age 50, the recommended daily amount is 1.5 mg for women and 1.7 mg for men. The recommended daily amount is higher for pregnant and breastfeeding women, with pregnant women expected to take 1.9 mg per daily and lactating mothers to take 2 mg daily. You can either take a vitamin B supplement that contains other B vitamins or you can take a pure vitamin B6 supplement to meet your needs. Regardless, you should check the amount provided in the product to avoid exceeding the maximum daily intake. Generally, adults older than 18 shouldn’t take more than 100 mg per day, while those between 14 and 18 years should not exceed 80 mg.

Third-party testing

Third-party testing evaluates the quality of a product, and it is usually done by an organization independent from the supplement company itself. If you want to be sure that the information on the package of your vitamin B6 supplement is accurate, you can look out for third-party certification on the product label. This type of certification indicates that the manufacturing, packaging, labeling and storing of the supplement adhere to industry standards. Independent testing provided by organizations like NSF international, Labdoor and ConsumerLab can also verify if the product is vegan-friendly, gluten-free or free from genetically modified ingredients. 

What to look for in a quality vitamin B6 supplement

Other ingredients

While some B6 supplements only contain vitamin B6 as the active ingredient, some formulations may include other vitamins and minerals like the other B vitamins and calcium. If you’re pregnant and looking to take a vitamin B6 supplement, you can take your regular prenatal vitamins, since they contain the amount of vitamin B6 you need during your pregnancy. However, if you are vitamin B6-deficient, you may choose the pure formulation of vitamin B6, but you shouldn’t exceed the upper daily limit of this vitamin, which is 100 mg.


Vitamin B6 supplements come in different forms, including tablets, capsules and powders. While the tablets and capsules are usually easy to take, the powder form can help you more accurately measure your doses. To make the pill form easy to take, there are great-tasting gummies and flavored dissolvable options that contain vitamin B6.


There are both low-dose and high-dose vitamin B6 formulations. The small-dose formulations come as 25 mg of vitamin B6, while the high-dose option contains 100 mg of vitamin B6 per capsule. You can choose to take either of these options, depending on your condition. However, it is recommended that you don’t exceed the maximum daily limit of 100 mg. 

How much you can expect to spend on a vitamin B6 supplement

When buying your vitamin B6 supplement, a low price point doesn’t necessarily mean the product is inexpensive. The best way to get the true cost of the product is to divide the cost of the product by the number of servings. On average, B6 supplements cost between $6 and $20 for bottles that contain between 60 and 250 tablets.

Vitamin B6 supplement FAQ

What drugs can cause vitamin B6 deficiency?

A. Taking anti-inflammatory drugs like dexamethasone, prednisone and hydrocortisone and antibiotics like rifampicin, ethambutol and isoniazid can deplete your vitamin B6 levels. To avoid this deficiency, you can take a vitamin B6 supplement when using any of these drugs.

What are the side effects of taking a vitamin B6 supplement?

A. When you take a vitamin B6 supplement, it may cause nausea, headache, stomach pain and loss of appetite. Taking doses that exceed 500mg is also not recommended, as this can cause brain or nerve problems.

What are the best vitamin B6 supplements to buy?

Top vitamin B6 supplement

Solgar Vitamin B6 25 mg, 100 Tablets

Solgar Vitamin B6 25 mg, 100 Tablets

What you need to know: This is a vegan-friendly vitamin B6 supplement that is also gluten-, wheat- and dairy-free.

What you’ll love: This supplement is free of gluten, and doesn’t contain artificial ingredients or fillers. The tablets are stored in a recyclable amber glass bottle, which is an excellent way to protect the vitamins from deterioration due to heat, light or moisture.

What you should consider: If you’re pregnant, it may cause nausea or worsen your morning sickness.

Where to buy: Sold by Amazon and iHerb

Top vitamin B6 supplement for the money

Nutricost Vitamin B6 100mg, 240 Capsules

Nutricost Vitamin B6 100mg, 240 Capsules

What you need to know: This vitamin B6 supplement is a non-GMO, gluten-free product that contains 240 vitamin B6 capsules.

What you’ll love: This supplement is made in a facility that complies with the U.S. Food & Drug Administration Current Good Manufacturing Practices. The product is also third-party tested, so you’re assured of the quality, potency and purity.

What you should consider: Some users found the pills difficult to swallow because of their size.

Where to buy: Sold by Amazon 

Worth checking out

EZ Melts B6 as Pyridoxine, 50 mg, Sublingual Vitamins

EZ Melts B6 as Pyridoxine, 50 mg, Sublingual Vitamins

What you need to know: This supplement contains orange-flavored dissolvable vitamin B6 tablets that are formulated to support your nervous system and heart health.

What you’ll love: The tablets are made using fast-melting technology, which makes them easy to take. The ingredients used in formulating the tablets are also third-party tested, which verifies their quality and potency.

What you should consider: Despite the orange flavor, some users still complained that they aren’t pleasant-tasting

Where to buy: Sold by Amazon

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Ayotola Ogunsipe writes for BestReviews. BestReviews has helped millions of consumers simplify their purchasing decisions, saving them time and money.

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